Two postdoctoral research positions available in developmental neurobiology

Torii and Hashimoto-Torii labs at Children’s National Health System in Washington DC have two opening postdoc positions supported by NIH funding. These positions will be paid according to the NIH payscale. Health insurance and other benefits will be provided by Children’s National.

One of the position seeks a person who has a strong background in molecular biology, biochemistry or systems biology (bioinformatics). The other position is available for a person who has experience in in vivo imaging or electrophysiology, and molecular genetics. Each will have a primary position in either of the two labs. However, since Torii lab and Hashimoto-Torii lab closely collaborate and share the resources, they are expected to join the collaborative projects between the labs.

Research in the Torii lab focuses on deciphering the complex mechanisms of cell positioning and neural circuit formation in the developing cerebral cortex, and translating the findings into the development of novel therapeutic approaches for neurodevelopmental disorders such as schizophrenia and autism. Toward this goal, the lab uses various tools and techniques, including in vivo gene manipulation, induced pluripotent stem (iPS) cells, transgenic animals and animal disease models, proteomic and transcriptomic analyses, and cell transplantation.

The Hashimoto-Torii lab seeks to understand how an adverse prenatal environment interacts with genetic predisposition, thereby increasing disease susceptibility after birth. Harmful conditions, such as hypoxia, exposure to excessive levels of heavy metals, and maternal smoking and alcohol intake are thought to reprogram normal fetal brain development and consequently increase the incidence of many childhood disorders, including lower birth weight, SIDS, pediatric epilepsy, schizophrenia and ADHD. However, the mechanisms underlying such reprogramming remain unknown. With a focus on the cerebral cortex, the team tackles this question through a combination of wet and dry analyses using mouse and human research models. The lab is also testing novel drugs and devices to improve behavioral problems in the offspring after in utero exposure to harmful agents.

If interested, please send a statement of your research interests and career goals, along with your CV and contact information of two references to mtorii@childrensnational.org and khtorii@childrensnational.org.